Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin Induces Apoptosis in Nonproliferating Macrophages by a Phosphatase-Independent Mechanism

Aggregatibacter actinomycetemcomitans strains that express cytolethal distending toxin (Cdt) are associated with localized aggressive periodontitis. However, the in vivo targets of Cdt in the human oral cavity have not been firmly established. Here, we demonstrate that A. actinomycetemcomitans Cdt k...

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Bibliographic Details
Main Authors: Rabin, Shira D. P., Flitton, Jared G., Demuth, Donald R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715655/
https://ncbi.nlm.nih.gov/pubmed/19470743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01227-08
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