Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 Protein

Although flaviviruses cause significant human diseases, no effective therapy is currently available. Host factors essential for viral replication are potential targets for antiviral development. Here we report that cyclophilins (CyPs), a family of cellular peptidyl-prolyl isomerases (PPIases), play...

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Autors principals: Qing, Min, Yang, Feng, Zhang, Bo, Zou, Gang, Robida, John M., Yuan, Zhiming, Tang, Hengli, Shi, Pei-Yong
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715601/
https://ncbi.nlm.nih.gov/pubmed/19451286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00189-09
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