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Pharmacodynamics of Levofloxacin in a Murine Pneumonia Model of Pseudomonas aeruginosa Infection: Determination of Epithelial Lining Fluid Targets

The dose choice for Pseudomonas aeruginosa remains a matter of debate. The actual exposure targets required for multilog killing of organisms at the primary infection site have not been delineated. We studied Pseudomonas aeruginosa PAO1 using a murine model of pneumonia. We employed a large mathemat...

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Autors principals: Louie, Arnold, Fregeau, Christine, Liu, Weiguo, Kulawy, Robert, Drusano, G. L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715581/
https://ncbi.nlm.nih.gov/pubmed/19364849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00006-09
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