Impact of the Epithelial Lining Fluid Milieu on Amikacin Pharmacodynamics Against Pseudomonas aeruginosa

BACKGROUND: Even though nebulised administration of amikacin can achieve high epithelial lining fluid concentrations, this has not translated into improved patient outcomes in clinical trials. One possible reason is that the cellular and chemical composition of the epithelial lining fluid may inhibi...

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Dettagli Bibliografici
Pubblicato in:Drugs R D
Autori principali: Heffernan, Aaron J., Sime, Fekade B., Lim, Sazlyna Mohd Sazlly, Naicker, Saiyuri, Andrews, Katherine T., Ellwood, David, Lipman, Jeffrey, Grimwood, Keith, Roberts, Jason A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2021
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Original Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8017437/
https://ncbi.nlm.nih.gov/pubmed/33797739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40268-021-00344-5
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