Oncogenic B-RAF Negatively Regulates the Tumor Suppressor LKB1 to Promote Melanoma Cell Proliferation

The LKB1 – AMPK signaling pathway serves as a critical cellular sensor coupling energy homeostasis to cell growth, proliferation and survival. However, how tumor cells suppress this signaling pathway to gain growth advantage under conditions of energy stress is largely unknown. Here, we show that AM...

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Detaylı Bibliyografya
Asıl Yazarlar: Zheng, Bin, Jeong, Joseph H., Asara, John M., Yuan, Yuan-Ying, Granter, Scott R., Chin, Lynda, Cantley, Lewis C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715556/
https://ncbi.nlm.nih.gov/pubmed/19187764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.12.026
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