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Oncogenic NRAS Signaling Differentially Regulates Survival and Proliferation in Melanoma
The discovery of potent BRAF inhibitors has revolutionized therapy for BRAF-mutant melanoma, yet NRAS-mutant melanoma remains without effective therapy. Since direct pharmacological inhibition of RAS has thus far been unsuccessful, we explored system biology approaches to identify synergistic drug c...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3777533/ https://ncbi.nlm.nih.gov/pubmed/22983396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2941 |
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