Oncogenic NRAS Signaling Differentially Regulates Survival and Proliferation in Melanoma

The discovery of potent BRAF inhibitors has revolutionized therapy for BRAF-mutant melanoma, yet NRAS-mutant melanoma remains without effective therapy. Since direct pharmacological inhibition of RAS has thus far been unsuccessful, we explored system biology approaches to identify synergistic drug c...

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Bibliografiske detaljer
Main Authors: Kwong, Lawrence N, Costello, James C, Liu, Huiyun, Genovese, Giannicola, Jiang, Shan, Jeong, Joseph H, Bender, Ryan P, Collins, James J, Chin, Lynda
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3777533/
https://ncbi.nlm.nih.gov/pubmed/22983396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2941
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