Profound CD4(+)/CCR5(+) T cell expansion is induced by CD8(+) lymphocyte depletion but does not account for accelerated SIV pathogenesis

Depletion of CD8(+) lymphocytes during acute simian immunodeficiency virus (SIV) infection of rhesus macaques (RMs) results in irreversible prolongation of peak-level viral replication and rapid disease progression, consistent with a major role for CD8(+) lymphocytes in determining postacute-phase v...

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Bibliografische gegevens
Hoofdauteurs: Okoye, Afam, Park, Haesun, Rohankhedkar, Mukta, Coyne-Johnson, Lia, Lum, Richard, Walker, Joshua M., Planer, Shannon L., Legasse, Alfred W., Sylwester, Andrew W., Piatak, Michael, Lifson, Jeffrey D., Sodora, Donald L., Villinger, Francois, Axthelm, Michael K., Schmitz, Joern E., Picker, Louis J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2009
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715089/
https://ncbi.nlm.nih.gov/pubmed/19546246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090356
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