Profound CD4(+)/CCR5(+) T cell expansion is induced by CD8(+) lymphocyte depletion but does not account for accelerated SIV pathogenesis

Depletion of CD8(+) lymphocytes during acute simian immunodeficiency virus (SIV) infection of rhesus macaques (RMs) results in irreversible prolongation of peak-level viral replication and rapid disease progression, consistent with a major role for CD8(+) lymphocytes in determining postacute-phase v...

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Bibliografiset tiedot
Päätekijät: Okoye, Afam, Park, Haesun, Rohankhedkar, Mukta, Coyne-Johnson, Lia, Lum, Richard, Walker, Joshua M., Planer, Shannon L., Legasse, Alfred W., Sylwester, Andrew W., Piatak, Michael, Lifson, Jeffrey D., Sodora, Donald L., Villinger, Francois, Axthelm, Michael K., Schmitz, Joern E., Picker, Louis J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2009
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715089/
https://ncbi.nlm.nih.gov/pubmed/19546246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090356
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