Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

DNA cytosine methylation is crucial for retrotransposon silencing and mammalian development. In a computational search for enzymes that could modify 5-methylcytosine (5mC), we identified TET proteins as mammalian homologs of the trypanosome proteins JBP1 and JBP2, which have been proposed to oxidize...

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Detaylı Bibliyografya
Asıl Yazarlar: Tahiliani, Mamta, Koh, Kian Peng, Shen, Yinghua, Pastor, William A., Bandukwala, Hozefa, Brudno, Yevgeny, Agarwal, Suneet, Iyer, Lakshminarayan M., Liu, David R., Aravind, L., Rao, Anjana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2715015/
https://ncbi.nlm.nih.gov/pubmed/19372391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1170116
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