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Conformational change in the Bacillus subtilis RNase P holoenzyme–pre-tRNA complex enhances substrate affinity and limits cleavage rate
Ribonuclease P (RNase P) is a ribonucleoprotein complex that catalyzes the 5′ maturation of precursor tRNAs. To investigate the mechanism of substrate recognition in this enzyme, we characterize the thermodynamics and kinetics of Bacillus subtilis pre-tRNA(Asp) binding to B. subtilis RNase P holoenz...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2009
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714742/ https://ncbi.nlm.nih.gov/pubmed/19549719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.1639409 |
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