A West Nile Virus DNA Vaccine Induces Neutralizing Antibody in Healthy Adults during a Phase 1 Clinical Trial

BACKGROUND: West Nile virus (WNV) is a mosquitoborne flavivirus that can cause severe meningitis and encephalitis in infected individuals. We report the safety and immunogenicity of a WNV DNA vaccine in its first phase 1 human study. METHODS: A single-plasmid DNA vaccine encoding the premembrane and...

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Detalhes bibliográficos
Main Authors: Martin, Julie E., Pierson, Theodore C., Hubka, Sarah, Rucker, Steve, Gordon, Ingelise J., Enama, Mary E., Andrews, Charla A., Xu, Qing, Davis, Brent S., Nason, Martha C., Fay, Michael P., Koup, Richard A., Roederer, Mario, Bailer, Robert T., Gomez, Phillip L., Mascola, John R., Chang, Gwong-Jen J., Nabel, Gary J., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714735/
https://ncbi.nlm.nih.gov/pubmed/18190252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/523650
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