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Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains
Loss of PTEN causes unregulated activation of downstream components of phosphatidylinositol 3-kinase (PI3K) signaling, including PDK1, and disrupts normal nervous system development and homeostasis. We tested the contribution of Pdk1 to the abnormalities induced by Pten deletion in the brain. Condit...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2009
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714713/ https://ncbi.nlm.nih.gov/pubmed/19605683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1799609 |
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