Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains

Loss of PTEN causes unregulated activation of downstream components of phosphatidylinositol 3-kinase (PI3K) signaling, including PDK1, and disrupts normal nervous system development and homeostasis. We tested the contribution of Pdk1 to the abnormalities induced by Pten deletion in the brain. Condit...

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Bibliografiske detaljer
Main Authors: Chalhoub, Nader, Zhu, Guo, Zhu, Xiaoyan, Baker, Suzanne J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2009
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714713/
https://ncbi.nlm.nih.gov/pubmed/19605683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1799609
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