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Huntingtin promotes cell survival by preventing Pak2 cleavage
Huntington's disease is caused by a polyglutamine expansion in the huntingtin protein. Wild-type huntingtin, by contrast, appears to protect cells from pro-apoptotic insults. Here we describe a novel anti-apoptotic function for huntingtin. When cells are exposed to Fas-related signals, the ubiq...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Company of Biologists
2009
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714430/ https://ncbi.nlm.nih.gov/pubmed/19240112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.050013 |
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