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PAK2 links cell survival to mechanotransduction and metabolism
Too little or too much force can trigger cell death, yet factors that ensure the survival of cells remain largely unknown. Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Int...
Gespeichert in:
| Veröffentlicht in: | J Cell Biol |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Rockefeller University Press
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6548143/ https://ncbi.nlm.nih.gov/pubmed/30940647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807152 |
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