PAK2 links cell survival to mechanotransduction and metabolism

Too little or too much force can trigger cell death, yet factors that ensure the survival of cells remain largely unknown. Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Int...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Campbell, Hannah K., Salvi, Alicia M., O’Brien, Timothy, Superfine, Richard, DeMali, Kris A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548143/
https://ncbi.nlm.nih.gov/pubmed/30940647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807152
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