Vinculin phosphorylation differentially regulates mechanotransduction at cell–cell and cell–matrix adhesions

Cells experience mechanical forces throughout their lifetimes. Vinculin is critical for transmitting these forces, yet how it achieves its distinct functions at cell–cell and cell–matrix adhesions remains unanswered. Here, we show vinculin is phosphorylated at Y822 in cell–cell, but not cell–matrix,...

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Bibliographic Details
Main Authors: Bays, Jennifer L., Peng, Xiao, Tolbert, Catlin E., Guilluy, Christophe, Angell, Ashley E., Pan, Yuan, Superfine, Richard, Burridge, Keith, DeMali, Kris A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2014
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4003237/
https://ncbi.nlm.nih.gov/pubmed/24751539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201309092
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