PAK2 links cell survival to mechanotransduction and metabolism

Too little or too much force can trigger cell death, yet factors that ensure the survival of cells remain largely unknown. Here, we demonstrate that E-cadherin responds to force by recruiting and activating p21-activated protein kinase 2 (PAK2) to allow cells to stiffen, metabolize, and survive. Int...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Campbell, Hannah K., Salvi, Alicia M., O’Brien, Timothy, Superfine, Richard, DeMali, Kris A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Rockefeller University Press 2019
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548143/
https://ncbi.nlm.nih.gov/pubmed/30940647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201807152
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