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An activating interaction between the unphosphorylated N-terminus of human liver pyruvate kinase and the main body of the protein is interrupted by phosphorylation
The initial 26 amino acids of human liver pyruvate kinase (L-PYK) are not present/observed in the crystal structure. This region includes Ser12, the site of hormone dependent phosphorylation. Truncating the N-terminus of L-PYK mimics the effects of phosphorylation by causing a decrease in apparent P...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714166/ https://ncbi.nlm.nih.gov/pubmed/19320443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900421f |
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