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Energetic coupling between an oxidizable cysteine and the phosphorylatable N-terminus of human liver pyruvate kinase()

During our efforts to characterize regulatory properties of human liver pyruvate kinase (L-PYK), we have noted that the affinity of the protein for PEP becomes reduced after several days post cell lysis. A 1.8Å crystallographic structure of L-PYK with the S12D mimic of phosphorylation indicates that...

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Autori principali: Holyoak, Todd, Zhang, Bing, Deng, Junpeng, Tang, Qingling, Prasannan, Charulata B., Fenton, Aron W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3572911/
https://ncbi.nlm.nih.gov/pubmed/23270483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301341r
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