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Distinguishing the interactions in the fructose-1,6-bisphosphate binding site of human liver pyruvate kinase that contribute to allostery

In the study of allosteric proteins, understanding which effector/protein interactions contribute to allosteric activation is important both for designing allosteric drugs and for understanding allosteric mechanisms. The anti-hyperglycemic target, human liver pyruvate kinase (hL-PYK), binds its allo...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Ishwar, Arjun, Tang, Qingling, Fenton, Aron W.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286843/
https://ncbi.nlm.nih.gov/pubmed/25629396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501426w
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