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Distinguishing the chemical moiety of phosphoenolpyruvate that contributes to allostery in muscle pyruvate kinase
A series of substrate analogues has been used determine which chemical moieties of the substrate, phosphoenolpyruvate (PEP) contribute to the allosteric inhibition of rabbit muscle pyruvate kinase (M(1)-PYK) by phenylalanine. Replacing the carboxyl group of the substrate with a methyl alcohol, or re...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3548419/ https://ncbi.nlm.nih.gov/pubmed/23256782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301628k |
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