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Distinguishing the interactions in the fructose-1,6-bisphosphate binding site of human liver pyruvate kinase that contribute to allostery
In the study of allosteric proteins, understanding which effector/protein interactions contribute to allosteric activation is important both for designing allosteric drugs and for understanding allosteric mechanisms. The anti-hyperglycemic target, human liver pyruvate kinase (hL-PYK), binds its allo...
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| Veröffentlicht in: | Biochemistry |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5286843/ https://ncbi.nlm.nih.gov/pubmed/25629396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi501426w |
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