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The evolutionarily conserved residue A653 plays a key role in HERG channel closing
Human ether-a-go-go-related gene (HERG) encodes the rapid, outwardly rectifying K(+) current I(Kr) that is critical for repolarization of the cardiac action potential. Congenital HERG mutations or unintended pharmaceutical block of I(Kr) can lead to life-threatening arrhythmias. Here, we assess the...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Science Inc
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2714020/ https://ncbi.nlm.nih.gov/pubmed/19406877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2008.166694 |
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