Functional Interactions between Distinct Sodium Channel Cytoplasmic Domains through the Action of Calmodulin

Sodium channels are fundamental signaling molecules in excitable cells, and are molecular targets for local anesthetic agents and intracellular free Ca(2+) ([Ca(2+)](i)). Two regions of Na(V)1.5 have been identified previously as [Ca(2+)](i)-sensitive modulators of channel inactivation. These includ...

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Detalhes bibliográficos
Main Authors: Potet, Franck, Chagot, Benjamin, Anghelescu, Mircea, Viswanathan, Prakash C., Stepanovic, Svetlana Z., Kupershmidt, Sabina, Chazin, Walter J., Balser, Jeffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Membrane Transport, Structure, Function, and Biogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659242/
https://ncbi.nlm.nih.gov/pubmed/19171938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806871200
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