Genetic Screening in C. Elegans Identifies Rho-GTPAse Activating Protein 6 as Novel HERG Regulator

The human ether-a-go-go related gene (HERG) constitutes the pore forming subunit of I(Kr), a K(+) current involved in repolarization of the cardiac action potential. While mutations in HERG predispose patients to cardiac arrhythmias (Long QT syndrome; LQTS), altered function of HERG regulators are u...

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Bibliografiske detaljer
Main Authors: Potet, Franck, Petersen, Christina I., Boutaud, Olivier, Shuai, Wen, Stepanovic, Svetlana Z., Balser, Jeffrey R., Kupershmidt, Sabina
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2708093/
https://ncbi.nlm.nih.gov/pubmed/19038263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2008.10.015
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