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Structure of C3b-factor H and implications for host protection by complement regulators

Factor H (FH) is an abundant regulator of complement activation and protects host cells from self-attack by complement. Here we provide insights into the regulatory activity of FH by solving the crystal structure of the first four domains of FH in complex with its target C3b. FH interacts with multi...

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Detalhes bibliográficos
Main Authors: Wu, Jin, Wu, You-Qiang, Ricklin, Daniel, Janssen, Bert J.C., Lambris, John D., Gros, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713992/
https://ncbi.nlm.nih.gov/pubmed/19503104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1755
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