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Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster

Cis-natural antisense transcripts (cis-NATs) have been speculated to be substrates for endogenous RNA interference (RNAi), but little experimental evidence for such a pathway in animals has been reported. Analysis of massive Drosophila melanogaster small RNA data sets now reveals two mechanisms that...

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Bibliographic Details
Main Authors: Okamura, Katsutomo, Balla, Sudha, Martin, Raquel, Liu, Na, Lai, Eric C
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713754/
https://ncbi.nlm.nih.gov/pubmed/18500351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1438
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