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The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

In contrast to microRNAs and Piwi-associated RNAs, short interfering RNAs (siRNAs) are seemingly dispensable for host-directed gene regulation in Drosophila. This notion is based on the fact that mutants lacking the core siRNA-generating enzyme Dicer-2 or the predominant siRNA effector Argonaute 2 a...

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Bibliografiske detaljer
Main Authors: Okamura, Katsutomo, Chung, Wei-Jen, Ruby, J. Graham, Guo, Huili, Bartel, David P., Lai, Eric C.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735555/
https://ncbi.nlm.nih.gov/pubmed/18463630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07015
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