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Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals
In the canonical animal microRNA (miRNA) pathway, Drosha generates ∼60- to 70-nucleotide pre-miRNA hairpins that are cleaved by Dicer into small RNA duplexes that load into Argonaute proteins, which retain a single mature strand in the active complex. The terminal loops of some miRNA hairpins regula...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3639418/ https://ncbi.nlm.nih.gov/pubmed/23535236 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.211698.112 |
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