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Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals

In the canonical animal microRNA (miRNA) pathway, Drosha generates ∼60- to 70-nucleotide pre-miRNA hairpins that are cleaved by Dicer into small RNA duplexes that load into Argonaute proteins, which retain a single mature strand in the active complex. The terminal loops of some miRNA hairpins regula...

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Bibliographic Details
Main Authors: Okamura, Katsutomo, Ladewig, Erik, Zhou, Li, Lai, Eric C.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3639418/
https://ncbi.nlm.nih.gov/pubmed/23535236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.211698.112
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