Mode of Action of cGMP-dependent Protein Kinase-specific Inhibitors Probed by Photoaffinity Cross-linking Mass Spectrometry

The inhibitor peptide DT-2 (YGRKKRRQRRRPPLRKKKKKH) is the most potent and selective inhibitor of the cGMP-dependent protein kinase (PKG) known today. DT-2 is a construct of a PKG tight binding sequence (W45, LRKKKKKH, K(I) = 0.8 μm) and a membrane translocating sequence (DT-6, YGRKKRRQRRRPP, K(I) =...

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Main Authors: Pinkse, Martijn W. H., Rijkers, Dirk T. S., Dostmann, Wolfgang R., Heck, Albert J. R.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713552/
https://ncbi.nlm.nih.gov/pubmed/19369251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808521200
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