Synthetic peptides as cGMP-independent activators of cGMP-dependent protein kinase Iα

PKG is a multifaceted signaling molecule and potential pharmaceutical target due to its role in smooth muscle function. A helix identified in the structure of the regulatory domain of PKG Iα suggests a novel architecture of the holoenzyme. In this study, a set of synthetic peptides (S-tides), derive...

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Détails bibliographiques
Publié dans:Chem Biol
Auteurs principaux: Moon, Thomas M., Tykocki, Nathan R., Sheehe, Jessica L., Osborne, Brent W., Tegge, Werner, Brayden, Joseph E., Dostmann, Wolfgang R.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703045/
https://ncbi.nlm.nih.gov/pubmed/26687482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.11.005
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