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Synthetic peptides as cGMP-independent activators of cGMP-dependent protein kinase Iα
PKG is a multifaceted signaling molecule and potential pharmaceutical target due to its role in smooth muscle function. A helix identified in the structure of the regulatory domain of PKG Iα suggests a novel architecture of the holoenzyme. In this study, a set of synthetic peptides (S-tides), derive...
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| Опубликовано в: : | Chem Biol |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703045/ https://ncbi.nlm.nih.gov/pubmed/26687482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.11.005 |
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