Differential patterning of cGMP in vascular smooth muscle cells revealed by single GFP-linked biosensors

Here, we report the design of unprecedented, non-FRET based cGMP-biosensors, named FlincGs, to assess the dynamics of nitric oxide (NO) and atrial natriuretic peptide (ANP) induced synthesis of intracellular cGMP, [cGMP](i). Regulatory fragments of PKG I α, PKG I β, and an N-terminal deletion mutant...

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Bibliografiske detaljer
Main Authors: Nausch, Lydia W. M., Ledoux, Jonathan, Bonev, Adrian D., Nelson, Mark T., Dostmann, Wolfgang R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2008
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224218/
https://ncbi.nlm.nih.gov/pubmed/18165313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710387105
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