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Trans-Dominant Inhibition of Prion Propagation In Vitro Is Not Mediated by an Accessory Cofactor

Previous studies identified prion protein (PrP) mutants which act as dominant negative inhibitors of prion formation through a mechanism hypothesized to require an unidentified species-specific cofactor termed protein X. To study the mechanism of dominant negative inhibition in vitro, we used recomb...

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Detalles Bibliográficos
Main Authors: Geoghegan, James C., Miller, Michael B., Kwak, Aimee H., Harris, Brent T., Supattapone, Surachai
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713408/
https://ncbi.nlm.nih.gov/pubmed/19649330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000535
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