Irreversible Platelet Activation Requires Protease-Activated Receptor 1-Mediated Signaling to Phosphatidylinositol Phosphates

Thrombin induces platelet activation through an early, reversible stage of platelet aggregation, which is followed by a later, irreversible stage of platelet aggregation. Without intervention, events leading to pathological platelet activation can result in vessel occlusion, acute coronary syndrome,...

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Detalhes bibliográficos
Main Authors: Holinstat, Michael, Preininger, Anita M., Milne, Stephen B., Hudson, W. James, Brown, H. Alex, Hamm, Heidi E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713123/
https://ncbi.nlm.nih.gov/pubmed/19483102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.056622
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