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The structure of Aβ42 C-terminal fragments probed by a combined experimental and theoretical study

The C-terminus of Aβ42 plays an important role in this protein's oligomerization and may therefore be a good therapeutic target for treatment of Alzheimer's disease. Certain C-terminal fragments (CTFs) of Aβ42 have been shown to disrupt oligomerization and strongly inhibit Aβ42-induced neu...

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Detalhes bibliográficos
Main Authors: Wu, Chun, Murray, Megan M., Bernstein, Summer L., Condron, Margaret M., Bitan, Gal, Shea, Joan-Emma, Bowers, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712569/
https://ncbi.nlm.nih.gov/pubmed/19356595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.01.029
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