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Aβ(39–42) Modulates Aβ Oligomerization but Not Fibril Formation

Recently, certain C-terminal fragments (CTFs) of Aβ42 have been shown to be effective inhibitors of Aβ42 toxicity. Here, we examine the interactions between the shortest CTF in the original series, Aβ(39–42) and full-length Aβ. Mass spectrometry results indicate that Aβ(39–42) binds directly to Aβ m...

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Detalhes bibliográficos
Main Authors: Gessel, Megan Murray, Wu, Chun, Li, Huiyuan, Bitan, Gal, Shea, Joan-Emma, Bowers, Michael T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271797/
https://ncbi.nlm.nih.gov/pubmed/22129303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201520b
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