Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

Acetaminophen (APAP)-induced liver toxicity occurs with formation of APAP-protein adducts. These adducts are formed by hepatic metabolism of APAP to N-acetyl-p-benzoquinone imine, which covalently binds to hepatic proteins as 3-(cystein-S-yl)-APAP adducts. Adducts are released into blood during hepa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: James, Laura P., Letzig, Lynda, Simpson, Pippa M., Capparelli, Edmund, Roberts, Dean W., Hinson, Jack A., Davern, Timothy J., Lee, William M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Pharmacology and Experimental Therapeutics 2009
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712440/
https://ncbi.nlm.nih.gov/pubmed/19439490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.108.026195
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