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Detection and Trapping of Intermediate States Priming Nicotinic Receptor Channel Opening

In the course of synaptic transmission in the brain and periphery, acetylcholine receptors (AChRs) rapidly transduce a chemical signal into an electrical impulse. The speed of transduction owes in large part to rapid ACh association and dissociation, implying a binding site relatively non-selective...

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Detalhes bibliográficos
Main Authors: Mukhtasimova, Nuriya, Lee, Won Yong, Wang, Hai-Long, Sine, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2712348/
https://ncbi.nlm.nih.gov/pubmed/19339970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07923
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