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Initial Coupling of Binding to Gating Mediated by Conserved Residues in the Muscle Nicotinic Receptor

We examined functional consequences of intrasubunit contacts in the nicotinic receptor α subunit using single channel kinetic analysis, site-directed mutagenesis, and structural modeling. At the periphery of the ACh binding site, our structural model shows that side chains of the conserved residues...

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Bibliografski detalji
Glavni autori: Mukhtasimova, Nuriya, Free, Chris, Sine, Steven M.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2266616/
https://ncbi.nlm.nih.gov/pubmed/15955875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200509283
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