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Binding to Gating Transduction in Nicotinic Receptors: Cys-Loop Energetically Couples to Pre-M1 and M2–M3 Regions

The nicotinic acetylcholine receptor (AChR) transduces binding of nerve-released ACh into opening of an intrinsic ion channel, yet the intraprotein interactions behind transduction remain to be fully elucidated. Attention has focused on the region of the AChR in which the β1–β2 and Cys-loops from th...

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Bibliografiske detaljer
Main Authors: Lee, Won Yong, Free, Chris R., Sine, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728446/
https://ncbi.nlm.nih.gov/pubmed/19279256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6185-08.2009
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