AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR

The metabolic sensor AMP-activated protein kinase (AMPK) has emerged as an important link between cellular metabolic status and ion transport activity. We previously found that AMPK binds to and phosphorylates CFTR in vitro and inhibits PKA-dependent stimulation of CFTR channel gating in Calu-3 bron...

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Detalhes bibliográficos
Main Authors: King, J Darwin, Fitch, Adam C., Lee, Jeffrey K., McCane, Jill E., Mak, Don-On Daniel, Foskett, J. Kevin, Hallows, Kenneth R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
Assuntos:
Membrane Transporters, Ion Channels, and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711654/
https://ncbi.nlm.nih.gov/pubmed/19419994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00677.2008
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