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Preferential Phosphorylation of R-domain Serine 768 Dampens Activation of CFTR Channels by PKA
CFTR (cystic fibrosis transmembrane conductance regulator), the protein whose dysfunction causes cystic fibrosis, is a chloride ion channel whose gating is controlled by interactions of MgATP with CFTR's two cytoplasmic nucleotide binding domains, but only after several serines in CFTR's r...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2217491/ https://ncbi.nlm.nih.gov/pubmed/15657296 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409076 |
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