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Severed Channels Probe Regulation of Gating of Cystic Fibrosis Transmembrane Conductance Regulator by Its Cytoplasmic Domains

Opening and closing of a CFTR Cl(−) channel is controlled by PKA-mediated phosphorylation of its cytoplasmic regulatory (R) domain and by ATP binding, and likely hydrolysis, at its two nucleotide binding domains. Functional interactions between the R domain and the two nucleotide binding domains wer...

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Main Authors: Csanády, László, Chan, Kim W., Seto-Young, Donna, Kopsco, David C., Nairn, Angus C., Gadsby, David C.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2000
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2233695/
https://ncbi.nlm.nih.gov/pubmed/10962022
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