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Thermodynamics of CFTR Channel Gating: A Spreading Conformational Change Initiates an Irreversible Gating Cycle

CFTR is the only ABC (ATP-binding cassette) ATPase known to be an ion channel. Studies of CFTR channel function, feasible with single-molecule resolution, therefore provide a unique glimpse of ABC transporter mechanism. CFTR channel opening and closing (after regulatory-domain phosphorylation) follo...

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Detalhes bibliográficos
Main Authors: Csanády, László, Nairn, Angus C., Gadsby, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151586/
https://ncbi.nlm.nih.gov/pubmed/17043148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200609558
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