Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH(2)-terminal Nucleotide Binding Domain and its Role in Channel Gating

CFTR, the protein defective in cystic fibrosis, functions as a Cl(−) channel regulated by cAMP-dependent protein kinase (PKA). CFTR is also an ATPase, comprising two nucleotide-binding domains (NBDs) thought to bind and hydrolyze ATP. In hydrolyzable nucleoside triphosphates, PKA-phosphorylated CFTR...

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Bibliographic Details
Main Authors: Basso, Claudia, Vergani, Paola, Nairn, Angus C., Gadsby, David C.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2234483/
https://ncbi.nlm.nih.gov/pubmed/12939393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308798
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