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Prolonged Nonhydrolytic Interaction of Nucleotide with CFTR's NH(2)-terminal Nucleotide Binding Domain and its Role in Channel Gating
CFTR, the protein defective in cystic fibrosis, functions as a Cl(−) channel regulated by cAMP-dependent protein kinase (PKA). CFTR is also an ATPase, comprising two nucleotide-binding domains (NBDs) thought to bind and hydrolyze ATP. In hydrolyzable nucleoside triphosphates, PKA-phosphorylated CFTR...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2234483/ https://ncbi.nlm.nih.gov/pubmed/12939393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308798 |
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