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In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer
The human ATP-binding cassette (ABC) protein CFTR (cystic fibrosis transmembrane conductance regulator) is a chloride channel, whose dysfunction causes cystic fibrosis. To gain structural insight into the dynamic interaction between CFTR's nucleotide-binding domains (NBDs) proposed to underlie...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1618097/ https://ncbi.nlm.nih.gov/pubmed/17036051 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601373 |
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