Characterization of Antibiotic Peptide Pores Using Cryo-EM and Comparison to Neutron Scattering

Magainin, a 23-residue antibiotic peptide, interacts directly with the lipid bilayer leading to cell lysis in a strongly concentration-dependent fashion. Utilizing cryo-electron microscopy, we have directly observed magainin interacting with synthetic DMPC/DMPG membranes. Visual examination shows th...

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Detalhes bibliográficos
Main Authors: Han, Mikyung, Mei, Yuan, Khant, Htet, Ludtke, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2009
Assuntos:
Membrane
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711362/
https://ncbi.nlm.nih.gov/pubmed/19580754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.04.039
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