Slowing Down Downhill Folding: A Three-Probe Study

The mutant Tyr(22)Trp/Glu(33)Tyr/Gly(46)Ala/Gly(48)Ala of λ repressor fragment [Formula: see text] was previously assigned as an incipient downhill folder. We slow down its folding in a cryogenic water-ethylene-glycol solvent (−18 to −28°C). The refolding kinetics are probed by small-angle x-ray sca...

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Autores principales: Kim, Seung Joong, Matsumura, Yoshitaka, Dumont, Charles, Kihara, Hiroshi, Gruebele, Martin
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2009
Materias:
Protein
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2711359/
https://ncbi.nlm.nih.gov/pubmed/19580767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2009.04.041
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