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Solvent-tuning the collapse and helix formation time scales of λ(6-85)(*)
The λ(6-85)(*) pseudo-wild type of lambda repressor fragment is a fast two-state folder (k(f) ≈ 35 μsec(−1) at 58°C). Previously, highly stable λ(6-85)(*) mutants with k(f) > 30 μsec(−1) have been engineered to fold nearly or fully downhill. Stabilization of the native state by solvent tuning mig...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242409/ https://ncbi.nlm.nih.gov/pubmed/17075136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062257406 |
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